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Bidkhori M, Akbarzadeh M, Fahimfar N, Larijani B, Nabipour I, Ostovar A et al . The Role of the SOST Gene in Identifying Postmenopausal Women at Risk for Low Bone Quality. sjsph 2025; 23 (1) :35-46
URL: http://sjsph.tums.ac.ir/article-1-6397-en.html
URL: http://sjsph.tums.ac.ir/article-1-6397-en.html
Mohammad Bidkhori1 
, Mahdi Akbarzadeh2 , Noushin Fahimfar3 , Bagher Larijani4 , Iraj Nabipour5 , Afshin Ostovar6 , Kourosh Holakouie-Naieni *7
, Mahdi Akbarzadeh2 , Noushin Fahimfar3 , Bagher Larijani4 , Iraj Nabipour5 , Afshin Ostovar6 , Kourosh Holakouie-Naieni *7
1- Ph.D. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran, Ph.D. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Science
2- Assistant Professor, Cellular and Molecular Endocrine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Assistant Professor, Cellular and Molecular Endocrine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- Assistant Professor, Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences; Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran, Assistant Professor, Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences; Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Science
4- Ph.D. Professor, Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran, Ph.D. Professor, Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
5- Ph.D. Professor, The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran, Ph.D. Professor, The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
6- Professor, Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran, Professor, Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
7- Ph.D. Professor, Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran ,holakouie.KHN@gmail.com
2- Assistant Professor, Cellular and Molecular Endocrine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Assistant Professor, Cellular and Molecular Endocrine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- Assistant Professor, Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences; Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran, Assistant Professor, Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences; Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Science
4- Ph.D. Professor, Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran, Ph.D. Professor, Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
5- Ph.D. Professor, The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran, Ph.D. Professor, The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
6- Professor, Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran, Professor, Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
7- Ph.D. Professor, Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran ,
Abstract: (662 Views)
Background and Aim: The Trabecular Bone Score (TBS) is a novel tool for assessing bone microarchitecture and identifying individuals at risk for osteoporotic fractures. This study aimed to evaluate the association between Single Nucleotide Polymorphisms (SNPs) of the SOST gene and TBS in Iranian postmenopausal women.
Materials and Methods: This study included 1/071 postmenopausal women from the Bushehr Elderly Health (BEH) Cohort study. Relationship between Seven independent SNPs in the SOST gene located on chromosome 17q21.31 were investigated with TBS L1–L4. Associations were tested using generalized linear models under additive, dominant, and recessive genetic models. A genetic score was also calculated by summing the weighted number of risk alleles based on the regression coefficients of the SNPs.
Results: After adjustment for age and Body Mass Index (BMI), SNP rs2023794-C showed a statistically significant association with TBS in the additive model (β = 0/ 03, P = 4/7×10⁻⁵, PFDR = 0/0003) and the dominant model (β = 0/033, P = 2/5×10⁻⁵, PFDR = 0/0003). Furthermore, higher genetic scores were positively associated with increased TBS values.
Conclusion: Our findings highlight the potential role of SOST gene variants and derived genetic score in predicting bone quality in postmenopausal women. These genes could aid in identifying individuals at higher risk of poor bone quality and in developing personalized osteoporosis prevention strategies.
Materials and Methods: This study included 1/071 postmenopausal women from the Bushehr Elderly Health (BEH) Cohort study. Relationship between Seven independent SNPs in the SOST gene located on chromosome 17q21.31 were investigated with TBS L1–L4. Associations were tested using generalized linear models under additive, dominant, and recessive genetic models. A genetic score was also calculated by summing the weighted number of risk alleles based on the regression coefficients of the SNPs.
Results: After adjustment for age and Body Mass Index (BMI), SNP rs2023794-C showed a statistically significant association with TBS in the additive model (β = 0/ 03, P = 4/7×10⁻⁵, PFDR = 0/0003) and the dominant model (β = 0/033, P = 2/5×10⁻⁵, PFDR = 0/0003). Furthermore, higher genetic scores were positively associated with increased TBS values.
Conclusion: Our findings highlight the potential role of SOST gene variants and derived genetic score in predicting bone quality in postmenopausal women. These genes could aid in identifying individuals at higher risk of poor bone quality and in developing personalized osteoporosis prevention strategies.
Keywords: Osteoporosis, SOST Gene, Trabecular Bone Score, Postmenopausal Women, Bushehr Elderly Health (BEH)
Type of Study: Research |
Subject:
Public Health
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