Volume 4, Issue 1 (2 2006)                   sjsph 2006, 4(1): 57-64 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Shafieezadeh T, Holakuei Naieni K, Fotohi A, Mahmoodi M. Familial aggregation of esophageal cancer in Babol district in the north of Iran. sjsph. 2006; 4 (1) :57-64
URL: http://sjsph.tums.ac.ir/article-1-217-en.html

Abstract:   (5615 Views)
Background and Aim: The aim of this study is to evaluate the familial aggregation of esophageal cancer in a defined population under coverage of Babol Research Station, Institute of Public Health Research, Tehran University of Medical Sciences, in one of the high incidence areas in north of Iran and to assess the risk of disease associated with first degree familial relationship.
Material and Methods:
In this study, the data of family members of three to four successive generations and family history of esophageal and other cancers were collected from esophageal cancer cases which occurred between 2001-2003 in Babol district. The pairwise odds ratio of logistic regression method with GEE2 approach used for familial aggregation of esophageal cancer within first degree family. The results have been adjusted on covariates of age and sex of each family member and age and sex of the proband .
Results:
The proportion of having a positive family history of esophageal cancer in first relatives is 3.09% (3.8 % in men and 2.3 % in female relatives). The pairwise odds ratio was 1.79 (95% CI :1.1 , 2/93) in first degree family and odds ratio between parent – offspring was 2.21 (95%CI :1.1 , 4/44)and relation between sibling was 1.92(95%CI: 0.87, 4.24) . It was not possible to look for any parent – parent pattern.
Conclustin: We found a familial aggregation between first degree relatives in this area.The association between parent–offspring suggests the presence of a genetic component in this disease.
Full-Text [PDF 175 kb]   (1992 Downloads)    
Type of Study: Research | Subject: General
Received: 2005/03/7 | Accepted: 2005/04/30 | Published: 2013/08/11

Add your comments about this article : Your username or Email:
Write the security code in the box

© 2017 All Rights Reserved | Journal of School of Public Health and Institute of Public Health Research

Designed & Developed by : Yektaweb